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Metabolism of Drugs and Other Xenobiotics

Skrevet av:Pavel Anzenbacher, Ulrich M. Zange
ISBN:9783527329038
Antall sider: 745
IMPN: Wiley-VCH Verlag GmbH
Utgiver navn: Wiley-VCH Verlag GmbH
Utgiver land:Germany
Utgiver sted: Weinheim
Målgruppe: Postgraduate, Research & ScholarlyProfessional & Vocational

GBP 125.00


Kort beskrivelse:
A practice-oriented desktop reference for toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body.

Lang beskrivelse:
A practice-oriented desktop reference for toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part briefly reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.

Innholdsfortegnelse:
INTRODUCTION Drug metabolizing enzymes - an overview Cytochromes P450 UDP glucuronosyltransferases Sulfotransferases Glutathione S-transferases Hydrolytic enzymes Transporting systems Transcriptional regulation of human drug-metabolizing cytochrome P450 enzymes Importance of pharmacogenomics METABOLISM OF DRUGS Introduction to drug metabolism Central nervous system drugs Cardiovascular drugs Anticancer drugs Antimicrobial agents Drugs against acute and chronic pain Drugs of Abuse including Designer Drugs Nicotine Metabolism and its Implication Metabolism of Alcohol and its Consequences NATURAL PRODUCTS Introduction and Overview Flavones St John?s wort (Hypericum perforatum L.) Food Components and Supplements ENVIRONMENTAL POLLUTANTS Introduction Environmental Estrogens: Estrogenic and Anti-Estrogenic Activities of Xenobiotics Biotransformation of Insecticides

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